Northern France Research Articles

The predictive performance of the ANCA renal risk score in patients over 65 years of age with renal ANCA-associated vasculitis

Abstract Background The anti-neutrophil cytoplasmic antibody (ANCA) renal risk score (ARRS) for predicting renal survival in ANCA-associated vasculitis (AAV) had not previously been validated in adults over 65 years of age and presenting impairments associated with an aging kidney, a high cardiovascular comorbidity burden, and prevalent microscopic polyangiitis. Methods We retrospectively studied a cohort of 192 patients over 65 years of age (median [interquartile range] age: 73 [68; 78]), including 17.2% with renal-limited vasculitis, 49.5% with microscopic polyangiitis and 33.3% with granulomatosis with polyangiitis, at six centres of northern France. The primary study endpoint was the cumulative incidence of end-stage kidney disease (ESKD, maintenance of dialysis for at least 3 months) at 12 months, with death considered as a competing event. Results The median serum creatinine concentration at diagnosis was 300 [202; 502] µmol/L, and 48 (25.0%) patients required dialysis at presentation. The ARRS was high in 43 (22.4%) patients, medium in 106 (55.2%), and low in 43 (22.4%). The cumulative incidence of ESKD at 12 months was 0% in the low-risk group, 13.0% [7.6–20.0] in the medium-risk group, and 44.0% [29.0–58.0] in the high-risk group (p < 0.001). In the subgroup of 149 patients presenting a medium or high score, the ARRS had a C-index of 0.66 [0.58–0.74] for the prediction of ESKD at 12 months; this rose to 0.86 [0.80–0.90] when dialysis status at diagnosis was included. Conclusion The ARRS was a poor predictor of kidney survival at 12 months among patients over 65 years of age with renal AAV involvement—especially in the high ARRS group. The addition of dialysis status at diagnosis as an additional clinical parameter might improve the ARRS's predictive performance.

Last interglacial in western Europe: 20 years of multidisciplinary research on the Eemian (MIS 5e) calcareous tufa sequence at Caours (Somme basin, France) – a review

The calcareous tufa sequence and associated Palaeolithic site of Caours were discovered in 2002 during a test‐pit campaign aimed at identifying last interglacial (MIS 5e) archives in the fluvial terrace system of the Somme basin, northern France. The presence of an outstanding stratigraphical succession with four in situ Palaeolithic layers within the tufa sequence has motivated archaeological excavations of the site since 2005. The first malacological studies and U‐series ages quickly showed that the sequence was mainly deposited during the Eemian interglacial (MIS 5e). After 20 years of investigations, we propose here a summary of this multidisciplinary research project including stratigraphy, sedimentology, geochronology, geochemistry, malacology, mammals, palaeovegetation and archaeology. By combining 25 dates obtained by U‐series, ESR/U‐series, TL and OSL methods, the Caours calcareous tufa sequence is securely dated to the Eemian (123.1±2.8 ka). Based on the summary of the whole information, we propose a robust and detailed reconstruction of the modification of the valley environments between the Late Saalian and the Early Weichselian. At the scale of northwestern Europe, Caours provides a reference terrestrial molluscs record for the Eemian interglacial, including the climatic optimum, that is also described in the same layers by δ18O and δ13C analyses on calcite and by mammal remains. Moreover, the 300‐m‐long transect crossing the fluvial terrace covered by the tufa sequence and the bottom valley formation, combined with the chronology established from U‐series and OSL ages, shows that the incision of the present‐day valley, leading to the setting of the Very Low Terrace, was achieved during the first stages of the Early Weichselian (MIS 5d–5c). From an archaeological point of view, the configuration of the Caours site is unique at the scale of western Europe and demonstrates the adaptation of Neandertals to a forested environment and to fully temperate conditions during the Eemian.

Changes in length-at-first return of a sea trout (Salmo trutta) population in northern France

Changes in length-at-first return of a sea trout (Salmo trutta) population in northern France

Molecular Identification and Subtype Analysis of Blastocystis sp. Isolates from Wild Mussels (Mytilus edulis) in Northern France.

Blastocystis sp. is the most common single-celled eukaryote colonizing the human gastrointestinal tract worldwide. Because of the proven zoonotic potential of this protozoan, sustained research is therefore focused on identifying various reservoirs of transmission to humans, and in particular animal sources. Numerous groups of animals are considered to be such reservoirs due to their handling or consumption. However, some of them, including mollusks, remain underexplored. Therefore, a molecular epidemiological survey conducted in wild mussels was carried out in Northern France (Hauts-de-France region) to evaluate the frequency and subtypes (STs) distribution of Blastocystis sp. in these bivalve mollusks. For this purpose, 100 mussels (Mytilus edulis) were randomly collected in two sampling sites (Wimereux and Dannes) located in the vicinity of Boulogne-sur-Mer. The gills and gastrointestinal tract of each mussel were screened for the presence of Blastocystis sp. by real-time polymerase chain reaction (qPCR) assay followed by direct sequencing of positive PCR products and subtyping through phylogenetic analysis. In parallel, sequences of potential representative Blastocystis sp. isolates that were previously obtained from temporal surveys of seawater samples at marine stations offshore of Wimereux were integrated in the present analysis. By taking into account the qPCR results from all mussels, the overall prevalence of the parasite was shown to reach 62.0%. In total, more than 55% of the positive samples presented mixed infections. In the remaining mussel samples with a single sequence, various STs including ST3, ST7, ST14, ST23, ST26 and ST44 were reported with varying frequencies. Such distribution of STs coupled with the absence of a predominant ST specific to these bivalves strongly suggested that mussels might not be natural hosts of Blastocystis sp. and might rather be carriers of parasite isolates from both human and animal (bovid and birds) waste. These data from mussels together with the molecular identification of isolates from marine stations were subsequently discussed along with the local geographical context in order to clarify the circulation of this protozoan in this area. The identification of human and animal STs of Blastocystis sp. in mussels emphasized the active circulation of this protozoan in mollusks and suggested a significant environmental contamination of fecal origin. This study has provided new insights into the host/carrier range and transmission of Blastocystis sp. and emphasized its potential as an effective sentinel species for water quality and environmental contamination.

Legitimation Processes for a Branch Museum Development in a Post-Industrial City: The Louvre-Lens Museum in France

This research explores the legitimation processes underpinning the implementation of specific urban policies in cities grappling with socio-economic challenges, such as in a post-industrial context. Focusing on Europe, where public authorities are seeking to enhance the socio-economic dynamics of post-industrial cities through cultural initiatives like branch museums, our research is based on a historical study of media relating to the establishment in 2012 of the Louvre-Lens museum in northern France. Within this framework, we reveal how institutional actors have performed strategies of legitimation to develop the Louvre-Lens. Our findings underscore the confluence of two primary strategies – economic and cultural –in an effort to navigate the complexities and tensions inherent in establishing a cultural offer in a disadvantaged post-industrial region. We conclude with a discussion about the broader implications of these strategies within the realm of macromarketing. We provide practical recommendations for practitioners and policy makers involved in the development of branch museums.

Mapping Europe renewable energy landscape: Insights into solar, wind, hydro, and green hydrogen production

The study offers an in-depth examination of the capabilities and output of renewable energy sources, specifically focusing on solar, wind, hydroelectric, and green hydrogen technologies, within 27 countries of the European Union (EU) and the United Kingdom (UK). The outcomes reveal significant strides in renewable energy production, with countries such as Austria, Belgium, and Germany leading in their respective sectors. Germany emerges as a frontrunner, with the highest total renewable energy production. The study also highlights the pivotal role of green hydrogen as an alternative fuel source, with Germany and France showcasing considerable production capacities. The relationship between electricity consumption and renewable energy potential indicates a trend towards countries with high energy demands leading the shift to renewable energy. Regional analysis uncovers areas such as Northern Sweden, Germany, and France as potential hubs for green electricity production due to their abundant renewable resources. The analysis identifies areas that have either an excess or shortage of renewable energy resources, highlighting the critical need for equilibrium between supply and demand. It emphasizes the advancements made by the EU and UK in shifting towards renewable energy sources and stresses the ongoing need for dedication to achieving sustainability objectives in energy.

Song, Landscape, and Identity in Medieval Northern France: Toward an Environmental History. By Jennifer Saltzstein

<i>Song, Landscape, and Identity in Medieval Northern France: Toward an Environmental History</i>. By Jennifer Saltzstein

Age and origin of closed depressions in the Paris Basin: A majority of marl pits dug since the Neolithic period?

Marling (limestone alkaline amendment) agrarian practices have a plurimillennial influence on soil pH and on soil-associated ecosystems. Although the earliest written records in Europe date back to antiquity, the origin of this agrarian practice is not well known. In order to trace the evolution of this practice in the early agrarian societies of Western Europe, we searched for topographic anomalies of ancient limestone quarries that may have been used for marling. Four hundred circular closed topographic depressions (CDs) were identified under two areas of ancient forest in northern France with Lidar digital elevation models (DEMs). Soils, morphology and archaeological context were studied and filling sediments were dated in several dozen CDs.The gaps in the carbonate rocks, soils with calcaric properties (scattered limestone fragments), unstratified fills, the absence of buried paleosols, and dates (OSL, C-14) later than the first local agricultural societies made it possible to recognise the CDs that may have served as limestone quarries. This was the case for most of the 30 CDs studied, leaving a minority of natural origin (suffosion, depressions of thermokarstic origins). Amongst the quarries identified, the preferential excavation of soft (friable) limestone and the location of these quarries in fossil agrarian plots led us to hypothesize that they were used for alkaline amendments of the cultivated fields. The quarries were filled from the Middle Neolithic to Late Antiquity, shortly before the period of afforestation of these former agrarian territories.

Descriptive study of general practitioner's practices and knowledge about Parkinson's disease in the north of France

BackgroundParkinson's disease (PD), the second most frequent neurodegenerative disease, constitutes a major public health challenge. A guide published by the French National Authority for Health in 2012 and revised in 2016 put forward recommendations for general practitioners (GP) planning care pathways for parkinsonian patients. It is well known that PD can be difficult to diagnose, and that when patients consult their GP, symptoms are often still limited and embedded in clinical uncertainty. This means the pathway to confirmed diagnosis of PD can be lengthy and uncertain. Consequently, it is important to identify the difficulties GPs encounter when caring for PD patients in order to help them better close the gaps in care strategies. MethodsWe conducted a descriptive cross-sectional survey in northern France to evaluate GP practices and knowledge about PD and their accordance with care pathway recommendations. The survey was conducted using a 30-item questionnaire sent to a sample of GPs. ResultsThere were 164 GPs who responded to the study questionnaire. The responding GPs generally followed current care pathway recommendations. In presence of a parkinsonian syndrome, 93.3% of the GPs reported systematically looking for an iatrogenic cause; 57.4% did not announce the diagnosis without the advice of a neurologist; 97.6% referred patients to a neurologist when they suspected PD; and 80.5% asked the neurologist to modify treatments. Our findings also revealed some difficult aspects of GP practices: only 2.5% had had additional training in neurology; only 53.6% felt comfortable with the diagnosis of PD; 63.6% prescribed additional exams for the diagnosis; most of the GPs were unaware of second-line treatments and their indications, and finally existence of PD expert centers was unknown for 85.2%. ConclusionsThese findings could be useful to guide implementation of new measures supporting more holistic care for PD patients; PD expert centers in France could provide complementary information and training for GPs.

Prospective modelling of operational offshore wind farms on the distribution of marine megafauna in the southern North Sea

Intense development of Offshore Wind Farms (OWFs) has occurred in the North Sea with several more farms planned for the near future. These OWFs pose a threat to marine megafauna stressing the need to mitigate the impact of human activities. To help mitigate impacts, the Before After Gradient (BAG) design was proposed. We explored the use of the BAG method on megafauna sightings recorded at different distances from OWFs in the southern North Sea. We predicted intra-annual variability in species distribution, then correlated species distribution with the presence of operational OWFs and investigated the potential impact the operation of prospective OWFs may have on species distribution. Four patterns of intra-annual variability were predicted: species most abundant in spring, in winter, in both spring and winter, or all year round. We recommend that future OWF constructions be planned in summer and early fall to minimise impact on cetaceans and that offshore areas off northern France and Belgium be avoided to minimise impact on seabirds. Our prospective analysis predicted a decreased density for most species with the operation of prospective OWFs. Prospective approaches, using e.g. a BAG design, are paramount to inform species conservation as they can forecast the likely responses of megafauna to anthropogenic disturbances.

Genomics of the expanding pine pathogen Lecanosticta acicola reveals patterns of ongoing genetic admixture.

Lecanosticta acicola is a fungal pathogen causing severe defoliation, growth reduction, and even death in more than 70 conifer species. Despite the increasing incidence of this species, little is known about its population dynamics. Two divergent lineages have been described that have now been found together in regions of France and Spain, but it is unknown how these mixed populations evolve. Here we present the first reference genome for this important plant pathogenic fungi and use it to study the population genomics of 70 isolates from an affected forest in the north of Spain. We find signs of introgression between the two main lineages, indicating that active mating is occurring in this region which could propitiate the appearance of novel traits in this species. We also study the phenotypic differences across this population based on enzymatic activities on 20 compounds.

Environmental and social inequalities in health: Neighborhood-level composite indices as a decision-making tool

The environmental health research carried out on a broad scale does not provide decision-makers with tools for managing environmental and social inequalities in health on a fine scale. The goal of the present study was to develop a method for neighborhood-level territorial diagnosis that decision-makers can use to incorporate health issues into their planning policies. The primary objective was to analyze composite spatial vulnerability and resilience indices in the Lille metropolitan area in northern France. The secondary objective was to refine these results by taking account of neighborhood-level characteristics. The study highlights the interest of transdisciplinary research and collaboration with local experts to effectively evaluate and address environmental health issue (more than 30 experts gathered and 12 thematic workshops organized). The results showed that the proposed method allows for the comparison of neighborhoods; however, certain specificities may be underestimated. The real importance of certain variables linked to specific contexts can be minimized, which can distort our understanding of the challenges these neighborhoods face. Analyzing the environmental and social inequalities in health in the metropolitan area's center vs. its belt made it possible to take better account of the characteristics of the areas studied.

Linking Gulf Stream air–sea interactions to the exceptional blocking episode in February 2019: a Lagrangian perspective

Abstract. The development of atmospheric blocks over the North Atlantic–European region can lead to extreme weather events like heat waves or cold air outbreaks. Despite their potential severe impact on surface weather, the correct prediction of blocking lifecycles remains a key challenge in current numerical weather prediction (NWP) models. Increasing evidence suggests that latent heat release in cyclones, the advection of cold air (cold air outbreaks, CAOs) from the Arctic over the North Atlantic, and associated air–sea interactions over the Gulf Stream are key processes contributing to the onset, maintenance, and persistence of such flow regimes. To better understand the mechanism connecting air–sea interactions over the Gulf Stream with changes in the large-scale flow, we focus on an episode between 20 and 27 February 2019, when a quasi-stationary upper-level ridge was established over western Europe accompanied by an intensified storm track in the northwestern North Atlantic. During that time, a record-breaking winter warm spell occurred over western Europe bringing temperatures above 20 ∘C to the United Kingdom, the Netherlands, and northern France. The event was preceded and accompanied by the development of several rapidly intensifying cyclones that originated in the Gulf Stream region and traversed the North Atlantic. To explore the mechanistic linkage between the formation of this block and air–sea interactions over the Gulf Stream, we adopt a Lagrangian perspective, using kinematic trajectories. This allows us to study the pathways and transformations of air masses that form the upper-level potential vorticity anomaly and interact with the ocean front. We establish that more than one-fifth of these air masses interact with the Gulf Stream in the lower troposphere, experiencing intense heating and moistening over the region due to the frequent occurrence of CAOs behind the cold front of the cyclones. Trajectories moistened by the advection of cold air over a warm ocean by one cyclone later ascend into the upper troposphere with the ascending airstream of a subsequent cyclone, fueled by the strong surface fluxes. These findings highlight the importance of CAOs in the Gulf Stream region, indicating that their intense coupling between the ocean and atmosphere plays a role in block development. Additionally, they provide a mechanistic pathway linking air–sea interactions in the lower troposphere and the upper-level flow.

Recent outbreaks of the spruce bark beetle Ips typographus in the UK: Discovery, management, and implications

The eight-toothed spruce bark-beetle Ips typographus is the most damaging insect pest of Norway spruce in Europe, and it poses a serious risk to spruce in other countries where it is not currently present but might be introduced. The beetle is not native to the UK and before 2018 it had not been found established anywhere within the country. In November 2018, however, several adult Ips typographus were found in a billet trap set up as part of annual surveys that the UK carries out to monitor for this and other quarantine bark beetle pests. The finding of adult beetles in the billet trap, a few miles south of Ashford in Kent, led to the discovery of a breeding population in an adjacent woodland. Delimiting surveys to 1 km and further surveys to 50 km showed that the infestation was confined to a single stand of Norway spruce. The stand was felled in January and February 2019, and the material destroyed, and beetles emerging on the site were trapped out using pheromone traps, billet piles and trap trees. These prompt actions eradicated the breeding population, but small numbers of adult Ips typographus continued to be caught on the outbreak site in 2020 and 2021. These captures, and numerous adult Ips typographus caught in pheromone traps set up across the region in response to the outbreak, indicate that incursions of adult Ips typographus are occurring on a regular basis, most likely from source populations in northern France and Belgium. The arrival of adult Ips typographus over a wide area and the potential for further outbreaks represents a continuing threat to spruce woodlands in south-east England, and has important implications for surveillance and monitoring and the management of spruce in this part of the UK.

Causeries scriptologiques posthumes avec Anthonij Dees : un rapide survol

Abstract This article examines two Old French corpora related to the Domaine d’Oïl (Northern France) from a dialectometric and scriptometric perspective, which go back to the Romance scholar Anthonij Dees (1928–2001). These are, on the one hand, his atlas of charters published in 1980 (digiDees 1980) and, on the other hand, an electronic corpus created in Salzburg as recently as 2006 (digiDees 1983). This is based on geolocalisation computations of Old French texts (from the 12th and 13th centuries), which, carried out by Dees in 1983, were only rediscovered by chance in Amsterdam in 2006 and subsequently transferred to Salzburg. In addition to these two medieval datasets, dialect data from the French linguistic atlas ALF (“Atlas linguistique de la France”, 1902–1910) are also analysed, which spatially align with the two medieval datasets. The dialectometric and scriptometric analyses carried out on these three electronic corpora aim primarily to compare the spatial depth structures found in them. For this purpose, the following dialectometric map types were examined: similarity maps, parameter maps and isoglottic syntheses. When comparing them, an astonishing similarity of the spatial profiles visible on them emerges. It should be noted, however, that a time span of 600 years lies between the Old French data analysed by Dees and those of the ALF. The spatial similarity of the depth structures found in them is therefore all the more striking.

The Architecture of Politics and the Politics of Architecture: A Comparative Approach to Parish Church Building and Civic Government in Late-Medieval Europe

Abstract Church construction was one of the most challenging, and most political, tasks undertaken by medieval cities. Comparing examples from across Europe reveals profound differences, however, in both the architecture of politics and the politics of architecture; that is, how building projects were administered and how their administration shaped their socio-political significance. Although ranging across the continent, this article is centered on construction in two representative cities: Vienna and London. While the former had a small number of churches, all under the direct control of the mayor and council, the latter had over a hundred, each overseen by locally appointed officers. In Vienna, church construction was, thus, an important field of activity for the city government, which oversaw the work and celebrated its own leadership of the project; in London, it lay outside civic control and offered local opportunities for domination by wealthy families. This difference can be found across the continent, separating the large, old cities of England, northern France, Spain, and the Low Countries, which could have numerous churches, from smaller towns and cities both in these places and across the rest of central, northern, and southern Europe, which typically had a single, major parish church and only a few subordinate ones. This article considers the implications of these two contrasting models—centralized and decentralized, civic and parochial, high government and local politics—on how architectural production functioned as a field of political activity and how church building shaped local distributions and articulations of power in medieval Europe.

Fallen fruit: A backup resource during winter shaping fruit fly communities

Abstract Fallen fruits provide important feeding and breeding substrates for insects such as Drosophilidae and can be a potential trophic reservoir when usual host fruits become scarce. Recently, two invasive fruit fly species, Drosophila suzukii and Chymomyza amoena, have become established in Europe and are expected to alter existing Drosophilidae communities. In this study, carried out between September 2021 and April 2022 in northern France, we aimed to disentangle the relative roles of microclimatic, landscape and local factors driving the diversity of the Drosophilidae community in decaying fruit across seasons. Minimum site temperature during the week preceding sampling and the proportion of rotten fruit tissue had the strongest positive influence on Drosophilidae abundance and species richness. Drosophilidae abundance also increased with urbanisation (portion of building cover) around the sampled trees. Decaying apples were important breeding sites for C. amoena across seasons, but provided a suboptimal substrate for D. suzukii, which was only present in late summer. This study sheds light on the important role of unharvested fallen crop fruit in maintaining the diversity of an insect family that is generally overlooked in field studies. It also emphasises the importance of considering multiple scales and factors when studying the interactions between invasive species, native species and their shared trophic resources. Finally, our data highlight the importance of the Drosophilidae community in recycling agricultural waste.

Fighting Feasting Fools: Nicolas de Clamanges and the Reform of Saints’ Feast Days

ABSTRACT The French humanist and reformer Nicolas de Clamanges (ca. 1363/64-1437) wrote a blistering treatise against new feasts, De nouis festiuitatibus, which contrasts with his related sermon praising the holy innocents, De sanctis innocentibus. This contrast is ironic because their feast during the Christmas season had become the occasion for out-of-control celebrations known as the Feast of Fools, especially in Clamanges’ northern France. This essay uncovers and contextualizes his complaints within his style of reform: he uses the early church as a model, for instance, and launches into rhetorical flourishes, especially in the sermon. The essay also compares Clamanges’ positions with those of his classmate Jean Gerson (1363-1429) and their shared mentor at the University of Paris Pierre d’Ailly (1351-1420). All three hoped that good devotions come from good intentions, but both intention and devotion must be patrolled for superstition and excess.

Metabarcoding reveals waterbird diet in a French Ramsar wetland: implications for ecosystem management

Environmental and/or climate changes, occurring at a global or local scale, can significantly impact the diets, health, and population dynamics of waterbirds. This study aimed to develop an effective tool, using DNA metabarcoding of fecal samples, for monitoring waterbird diets during the breeding season in a Ramsar freshwater wetland in Northern France. We collected bird feces across eight marshes with varying anthropic usage. The majority of samples (69%) were from five waterbird species: Eurasian coot (Fulica atra), Eurasian moorhen (Gallinula chloropus), mallard (Anas platyrhynchos), mute swan (Cygnus olor), and grey heron (Ardea cinerea). DNA was extracted from 116 samples, with plant and invertebrate primers used to undertake multi-marker metabarcoding. Despite a negative impact of uric acid on DNA amplification, we observed significant dietary variations among bird species and sampling sites. Wetland bird diets primarily consisted of four arthropod families, dominated by Chironomidae and Asellidae. The number of plant families detected was higher, consisting of 33 families, with Poaceae highly prevalent within wetland bird diets. This study shows that using DNA metabarcoding to explore interactions between waterbirds and trophic resources is a promising approach to assist wetland management and assess the effect of environmental changes.

Hemixerophilic forests in the caucasus

Hemixerophilic vegetation of the lower mountain belt belongs to the class Quercetea pubescenti-petraeae Jakucs (1960) 1961, order Orno-Cotinetalia Jakucs (1960) 1961. Hemixerophilic forests in the Caucasus are represented by two types: Oak hemixerophylic forests from Quercus pubescens Wiild. and forest from Carpinus orientalis Mill. The forests of Quercus pubescens are confined to the Sub-Mediterranean, where they are known under the name “shiblyak.” The northern boundary of the species spreads across Northern France, southern Belgium and Germany, where it grows in the forests of the Atlantic Europe on carbonate soils. Further, the border goes along the southern Carpathians (Romania) and Podillia to the Crimea and the Caucasus in the east. Fluffy forests are a link between evergreen Mediterranean forests and Central European deciduous deciduous forests. Quercus pubescens is a derivative of the tertiary flora that developed in the drier and warmer climate of low mountains in the Mediterranean region bordering on Central Europe..